- Coming north or south on I-5 take exit 253 (Stayton, Hwy 22, Detroit Lake)
- Go east on Hwy 22
- Turn right at Hwy 226 between mile post 22 and 23 (Mehama, Lyons)
- As you enter Lyons you will be on 5th Street, which will turn into Main Street.
- Santiam is located just after the turn at 611 Main Street, right at the corner of 6th and Main.
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